A comparison of some Ektar 100 scanned on a CoolScan V (35mm film scanner) and CoolScan 8000 (35mm/120 film scanner). Both scanned at 4000dpi. I was surprised by how much cleaner the 8000 scans are. On looking this up the CS8000 apparently has a more diffused light which minimises the grain. I was so surprised I checked the scanning parameters for both images and they were the same. Both scans were done with VueScan. I think the CS V image seems to be relatively dusty, but I only had low IR cleaning on. I normally use SilverFast on the CS V so that might be more than low IR in VueScan.
Film is Ektar 100, shot on Nikon FE10 with 50mm Series E lens.