Adobe's new Denoise is impressive. But, can it replace DxO's DeepPRIME XD in your workflow? For me, DxO's speed and non-destructive application still makes it king of my high-volume short-deadline event photography workflow. On my M1 Mac mini, Denoise takes 3x longer. And, not being able to make all my adjustments and then batch process on export is a deal-killer. But, Denoise does a really nice job, especially on skin tones, if it's used at 50% or less.
FWIW, someone on the DPR forums kindly pointed out to me that DxO's handling of skin tones in high-ISO images can be improved by dialing down or turning off Lens Sharpness.